Emma Jones on Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.
COMMENT This paper examines toxic α-synuclein in the endoplasmic reticulum (ER) of a mouse model of synucleinopathy and in brain tissue from people with Parkinson’s disease using antibodies against α-synuclein oligomers and phosphorylated forms. Determining the n